This study was designed to investigate (1) men's most likely and least likely actions in response to a vignette describing an episode of depression, (2) whether conformity to masculine norms related to the likelihood of men's responses, and (3) which masculinity norms were associated with men's responses. One hundred fifty-three mostly White and heterosexual undergraduate men were asked to read a vignette describing an episode of major depression, reported the likelihood of taking 20 separate actions in response to those symptoms, and completed the Conformity to Masculine Norms Inventory (Mahalik et al., Psychology of Men and Masculinity, 4: 3-25, 2003b). Results identified the most likely and least likely responses to depression, indicated that global masculinity significantly related to four of the responses, and found three orthogonally distinct sets of relationships between specific masculinity norms and those four responses to symptoms of depression.