The current article provides an overview and discussion of the practical, theoretical, and research implications of the Real Men. Real Depression campaign that was released by the National Institute of Mental Health in the spring of 2003. The components of the campaign are described and placed in the context of literatures on men, masculinity, and help seeking. Also included is a discussion of the strengths and potential limitations of several critical components of the campaign. The need for further research using these materials is emphasized.